Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Naftifine hydrochloride (Naftifine HCl) 是一种抗生素。它具有抗真菌活性,对皮肤真菌、曲霉、Sporothrix schenckii、假丝酵母属的酵母有抑制作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 247 | 现货 | ||
100 mg | ¥ 348 | 现货 | ||
500 mg | ¥ 838 | 现货 | ||
1 g | ¥ 1,390 | 现货 |
产品描述 | Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2, 3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride (Naftifine HCl) can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved. |
体外活性 | Naftifine exhibits an interesting in vitro spectrum of activity against dermatophytes (38 strains; minimal inhibitory concentration (MIC) range 0.1 to 0.2 mg/mL), aspergilli (6 strains; MIC range, 0.8 to 12.5 mg/mL), Sporothrix schenckii (2 strains; MICs, 0.8 and 1.5 mg/mL), and yeasts of the genus Candida (77 strains; MIC range, 1.5 to greater than 100 mg/mL). [1] The MIC of naftifine for C. albicans Δ63 is 100 mg/L in Sabouraud medium (initial pH 6.5). Naftifine (50 mg/L) gives greater than 99% inhibition of sterol biosynthesis both in whole cells and in cell extracts of C. albicans. The primary action of naftifine appears to be the blocking of fungal squalene epoxidation. [2] |
体内活性 | Naftifine HCl 2% cream results in clinical cure rate and clinical success rate of 33% and 84% after treatment for 4 weeks, and week 2 efficacy response rates in Naftifine HCl 2% subjects are all lower than at week 4 but are significantly higher than week 2 vehicle-treated counterparts. [3] Naftifine causes interruption of fungal ergosterol synthesis and accumulation of squalene in fungal organisms. Naftifine also has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine has shown good efficacy and safety for a variety of conditions and is a useful treatment that provides both antifungal action and relief of inflammatory signs and symptoms. Few adverse events have been noted with naftifine use, the most frequent being mild and transient burning, stinging, or itching in the application area. [4] |
别名 | Naftifungin, 盐酸萘替芬, Naftifine HCl, Naftin, Exoderil |
分子量 | 323.86 |
分子式 | C21H22ClN |
CAS No. | 65473-14-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (308.77 mM), Sonication is recommended.
H2O: 2.5 mg/mL (7.72 mM), Sonication is recommended.
Ethanol: 8 mg/mL (24.7 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O / Ethanol | 1 mM | 3.0878 mL | 15.4388 mL | 30.8775 mL | 77.1938 mL |
5 mM | 0.6176 mL | 3.0878 mL | 6.1755 mL | 15.4388 mL | |
DMSO / Ethanol | 10 mM | 0.3088 mL | 1.5439 mL | 3.0878 mL | 7.7194 mL |
20 mM | 0.1544 mL | 0.7719 mL | 1.5439 mL | 3.8597 mL | |
DMSO | 50 mM | 0.0618 mL | 0.3088 mL | 0.6176 mL | 1.5439 mL |
100 mM | 0.0309 mL | 0.1544 mL | 0.3088 mL | 0.7719 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Naftifine hydrochloride 65473-14-5 GPCR/G Protein Microbiology/Virology Stem Cells Hedgehog/Smoothened Antibiotic Antifungal Naftifine Hydrochloride Naftifungin tinea corporis 盐酸萘替芬 pedis cruris dermatophytes inhibit Naftifine HCl Naftifine Naftin Fungal Inhibitor Exoderil inhibitor